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PEP-1D - Radiation Safety Risk Mitigation in Y-90 Microsphere Administrations

Annapolis 4   08:00 - 10:00

PEP-1D.   Radiation Safety Risk Mitigation in Y-90 Microsphere Administrations WR Gibbons*, Moffitt Cancer Center ; KL Dillingham, The University of Chicago

Abstract: Selective Internal Radiation Therapy (SIRT) using Yttrium-90 (Y-90) microspheres is widely performed for radioembolization of primary or metastatic tumors within the liver. Intravascular administration of glass or resin microspheres containing radioactive isotopes is performed in interventional radiology and typically involves a multidisciplinary team composed of authorized users, medical physicists, and nuclear medicine technologists. As the number of Y-90 microsphere administrations increases, so too are the number of reported medical events. The December 2022 final report of the Nuclear Regulatory Commission Advisory Committee on the Medical Uses of Isotopes Y-90 Microsphere Medical Events Subcommittee reported 93 total medical events over 4 years from Y-90 microsphere administrations, more than double the number of events of the next highest source of medical events. This discussion will engage the audience and introduce key topics to those newly tasked with or interested in developing Y-90 microsphere programs while offering those more experienced an opportunity to review the fundamentals of such procedures and share personal insights related to the safe and effective use of Y-90 for radioembolization. This presentation will review reported types of medical events and explore various practices that can be implemented to improve a multidisciplinary Y-90 microsphere program and mitigate associated safety risks.

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