PEP-3B.
Important Radiation Biology Concepts for Radiation Protection KD Held*, NCRP
Abstract: A good understanding of basic radiation biology concepts and new information and research approaches is critical for understanding and applying radiation protection practices. In recent years there has been a plethora of new thoughts and data derived using state-of-the-art molecular biology techniques that impact the application of radiation biology knowledge to many aspects of radiation protection, particularly in the low dose and low dose rate arena. In addition to knowing “classic” concepts such as acute and delayed effects on irradiated normal tissues, sparing by low dose rates, and mechanisms of radiation carcinogenesis, a health physics practitioner should now be familiar with concepts such as bystander effects, genomic instability, DNA damage repair fundamentals, and genomics and proteomics. This lecture will provide an overview of important radiation biology fundamentals relevant to protecting workers, the public and medical patients exposed to radiation, as well as an introduction to newer findings that could impact future approaches to protection.
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